The measurement of plasma viscosity has high stability and accuracy, making small changes potentially clinically significant. Its normal value is 1.10-1.30 mPa*s at 37°C and remains independent of age and gender. Plasma is a Newtonian fluid, meaning its viscosity does not depend on flow characteristics, making it easy to measure, especially in capillary viscometers. The less spherical shape, higher molecular weight, higher aggregating capacity, and increased temperature or pH sensitivity of a protein all contribute to higher plasma viscosity results. The effect of a protein on plasma viscosity depends on its molecular weight and structure. As plasma is a highly concentrated protein solution, weak protein-protein interactions can play a role that is not characterized by electrophoresis. Plasma viscosity is determined by the water content and macromolecular components present. Despite being a valuable diagnostic tool, the evaluation of plasma viscosity has been underutilized in clinical practice.
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